Subklinik Hipotiroidizm ile Gestasyonel Diabetes Mellitus Arasındaki İlişki

Aim: The most common metabolic disorder during pregnancy is gestational diabetes mellitus (GDM). GDM can occur in anywhere between 1.7 and 11.6 percent of people. In hypothyroidism, the rates glucose oxidation glycogen synthesis are reduced, peripheral tissues' consumption also delayed. Patients with subclinical overt hypothyroidism develop insulin resistance because unable to adequately maintain muscles' use glucose. According literature, linked 6–15 pregnancies. Additionally, chance having 4.3 times higher pregnant women who have hypothyroidism. This study aimed reveal relationship first-trimester thyroid function tests GDM. 
 Material Method: retrospective cohort was conducted May 2021 2022. 100 patients diagnosed 500 healthy controls were included study. Using a 75 g challenge test, identified. trimester-specific recognized normal limits used evaluate TSH fT4 readings.
 Results: There statistically significant difference terms SCH without (p=0.04). TSH's performance predicting evaluated using AUC ROC (AUC=0.586 p=0.006). To forecast GDM, level cut-off value discovered be 1.58. found 0.586 (0.521-0.652). Furthermore, selectivity 58% sensitivity 41%
 Conclusion: many studies literature investigating functions development mellitus. Our correlation diagnosis first trimester adds importance being cautious vigilant based on results test trimester.